In easy phrases, it means that you could need to have Increasingly more of the identical drug to provide you with the similar feeling since the scaled-down sum you utilised if you initially began taking that drug.
The reduced response can not be reversed by rising the dose, this phenoenon termed as a tachyphylaxis. This mobile block receptor can be bettering by switching a drug which create exact same therapeutic motion. thirteen. Metabolic Disturbances :-
The alterations in acid, foundation and h2o electrolyte disturbance and overall body temperature may well change the effects of medicine.
0 The word posology is derived with the Greek words 'posos' this means how much and 'logos' that means science. So posology is really a branch of professional medical science which specials with dose or amount of medications that may be administered to the patient to acquire the specified pharmacological steps.
It might also be utilized to prevent sure kinds of coronary heart and blood vessel complications in sufferers with danger factors for heart issues.
Atorvastatin belongs to your team of medicines called HMG-CoA reductase inhibitors, or statins. It works by blocking an enzyme that is needed by your body for making cholesterol, and this lessens the level of cholesterol from the blood.
Aggressive/reversible antagonism: This is a phenomenon where by competitive antagonists contend with agonists for a typical binding web site over a receptor.
Photopharmacology is really an rising strategy in medication where drugs are activated and deactivated with light. The Electrical power of sunshine is utilised to vary for shape and chemical Homes from the drug, resulting in several biological activity.
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Therapeutic reaction will not be attained for a few days or various weeks; the dosage need to be lowered to the bottom effective dose after clinical effect is achieved.
Because the drug detoxification and excretion mechanisms current within the fetus are underdeveloped, concentrations of medicines may reach the next degree within the fetus than in the maternal circulation.
Human body excess weight-centered dosing consists of using a boy or girl’s fat to calculate the suitable dose of medication.
14. Tolerance: When an unusually get more info massive dose of a drug is required to elicit an affect ordinarily produced by the normal therapeutic dose with the drug, the phenomenon is termed as drug tolerance. e.g., smokers can tolerate nicotine, alcoholic can tolerate significant amount of Liquor.
The extent of education and learning affects the variable posology and the strategy of administration regarding the stage of knowledge only.